The winner of the Charlottesville Regional is set to face the Columbia Regional winner, featuring No. 8 national seed and back-to-back National Champion South Carolina.
In 2010, OU knocked off Virginia in a Super Regional en route to its first berth in Omaha since 1995 at the time.
It'll likely have to defeat the Cavaliers twice to advance, but the first task is a 39-16 Appalachian State Mountaineers squad that lost to Furman in the Southern Conference Championship.
The Mountaineers beat common foe Samford two out of three, as did the Sooners, so the opening matchup should be very competitive.
Play will open up Friday and go through Sunday/Monday.