In doing so, they suffocated the Horned Frogs to the lowest output in a half for an opponent since the 2003-04 season when they limited Arkansas-Pine Bluff to just nine points.
TCU's miniscule 11 points in the opening frame came on just 4-of-24 shooting.
"Good, good start to the ball game defensively," said OU head coach Lon Kruger. "I thought our guys really came out pretty sharp, pretty focused. Good effort."
Meanwhile, OU poured it on with a 36-point offensive barrage to go up by 25 at intermission.
"Offensively a little slow paced there early, but when we got that going a little bit, I thought pretty consistent start to finish," Kruger said.
Though TCU heated up some to eventually shoot 30 percent from the field, the Sooners maintained that lead throughout the remainder of the contest.
Again, OU shot the ball well, hitting 50 percent—29-of-58, to be exact—of its attempts.
And it was an evenly spread scoring distribution, with seven players scoring at least eight points and only two finishing in double figures.
Forwards Amath M'Baye and Romero Osby served as those two with 12 and 11 points, respectively.
"A lot of different guys making good plays for each other, and coming off the emotional win on Saturday, kind of interesting to see how we'd bounce back and thought they handled that very well, as they've done for the most part all season," Kruger said. "So, a lot of guys played well and that's a good thing."
Three players did so for the Horned Frogs in their hapless offensive effort.
TCU actually outrebounded OU 35-34 after trailing in that battle 21-16 at half.
But the Sooners, who posted 11 assists to just seven for the Horned Frogs, won just about every other battle.
As much as stats can tell about this game, though, the major storyline took place late in the second half, when freshman guard Buddy Hield came down awkwardly after a free throw.
OU's energy man known for strumming his air guitar during games and always having a smile on his face broke a toe in his right foot.
"It's not good," Kruger said. "You know, Buddy's got a fracture in the fifth metatarsal in that right foot, so we'll discuss the options tomorrow or later tonight and see where that goes. But it'll be a while before Buddy gets back and guys are [disappointed].
"I mean, Buddy—he loves to play obviously and it hurts everyone when that's taken away, so we're disappointed by that.
Kruger said immediately after the game on the radio that Hield could be out four to five weeks, meaning he'll miss the remainder of the conference season as well as possibly part of the Big 12 Conference Tournament and even the NCAA Tournament should OU make it there.
Winners of two straight after dropping a pair in a row, OU (16-7, 7-4 Big 12) now hopes to continue its streak without Hield when it takes on Bedlam rival Oklahoma State at 12:30 p.m. CT Saturday in a rematch at Gallagher-Iba Arena.