And for the second time this weekend, their offense exploded.
"They're a big momentum team," said OU head coach Patty Gasso. "And you asked—someone asked, 'Do you know?' And they won't say they know that they're good, but know that they're good.
"And they love to pass the bat or what we call pass the torch, keep the inning alive. That's why you see them respond with two outs."
Arkansas, on the other hand, couldn't come up with hardly anything offensively, mustering just three hits and scoring its lone run on a fourth inning homer by first baseman Devon Wallace.
Outside of that, it was all Sooners, who outscored their regional opponents by a combined 41-6 count in three games.
Second baseman Georgia Casey put OU on top early with her RBI single into left field in the top of the first.
A pair of runs scored in the third on right fielder Callie Parsons' misplayed fly to right, and Chamberlain, who banged out 13 RBI this weekend, delivered the big three-run jack moments after to cap off a five-spot.
"The ball was just looking pretty big today, I'm just gonna say that," Chamberlain said. "It was just like a very good pitch."
OU topped that with a crooked six-spot in the fourth that featured Pendley's homer, catcher Jessica Shults' two-run double to the wall in center and another run-scoring hit by Pendley, a two-run single, as OU batted around.
Henson got into the fray with her two-RBI round-tripper to left in the fifth.
As many expected, the Sooners (50-4) left no doubt in the Norman Regional as they completed a perfect weekend and didn't require any drama in the championship.
"Our goal was to make it one game, and that was the focus and that was the commitment," Gasso said. "And they were locked in and ready to go, so I'm very proud of them."
They proved to be nothing less than dominant, appearing yet again as the number one team in the land with their precision in all areas.
Now they'll host former Big 12 Conference foe Texas A&M in next week's Super Regional round slated for a game one start at 6 p.m. CT Thursday.