Winners of the Charlottesville Super Regional in 2010 en route to making the College World Series and Charlottesville Regional once again last season, OU now heads back to the state of Virginia, but with a battle with Virginia's rival, the Virginia Tech Hokies, on tap this time around.
The Sooners will arrive as the No. 2 seed poised for a contest with No. 3 Coastal Carolina.
When they get there, they'll be looking to extend their season in Virginia for the third time in the last four seasons.
Top-seeded Virginia Tech takes on No. 4 UConn in the double elimination format.
If OU triumphs, it'll likely have a trip to Alex Box Stadium and No. 4 national seed LSU in store.
The Sooners, losers of nine out of 11 heading into the final game of the regular season, have since rolled off five straight, including a perfect 4-0 showing in Oklahoma City on their way to their first Big 12 Championship since 1997.
With their Big 12 Title victory over Kansas, the Sooners (40-19) became one of just three teams to post at least 40 victories in each of the past five seasons.
It's their sixth straight tournament appearance and ninth in the last 10 seasons.