Knight remained in the game until the fourth quarter, throwing a touchdown pass to Sterling Shepard on the first play of the quarter, as Oklahoma gained nearly 300 yards of offense in the first half and finished with 580 yards.
Shepard had a career-high 177 yards on eight catches. He also scored one touchdown.
The Sooners’ defense held Tulsa (1-1) to just 95 yards in the first half and scored a touchdown of its own on a Geneo Grissom interception. Oklahoma (2-0) nearly had a second defensive touchdown but Jordan Phillips fumble recovery return in the first half was called back after a penalty.
Oklahoma, which will play Tennessee next week in its marquee non-conference matchup, ran for four touchdowns – one by Knight, an 80-yard score by Alex Ross and a pair of touchdowns from Keith Ford, who emerged as the dominant running back in the backfield.
Ford finished with 10 carries and 87 yards while Ross and Perine combined for 15 carries and 123 yards behind a dominant offensive line that allowed the Sooners to gain 8.4 yards per play even after the second-team came in for much of the fourth quarter.
Oklahoma, which scored 21 points in the first quarter, committed no turnovers in the game but forced Tulsa into four, including a pick 6 by Geneo Grissom and a late INT by linebacker Caleb Gastelum, who was awarded a scholarship after the game.
Cornerback Zack Sanchez suffered a right arm injury in the first half that kept him out of the game. Linebacker Jordan Evans, safety Quentin Hayes and defensive lineman Charles Walker also both suffered injuries in the wet mess of Tulsa’s field. However, Evans returned immediately.