The Sooners threw the ball just twice in the first 21 minutes of the second half and rushed for 384 yards, two games after eclipsing the 500-yard mark against Iowa State.
Coming off an embarrassing loss to Baylor, Oklahoma (7-3, 4-3 Big 12) handed the ball off to true freshman Samaje Perine, who finished with 213 yards on 25 carries and scored three touchdowns. Perine, who finished with more than 100 yards after contact and eclipsed 1,000 yards on the season for Oklahoma for the first time since 2010, was also indirectly responsible for two more touchdowns as the Red Raiders (3-7, 1-6) focused almost exclusively on stopping the young running back in the second half.
Marred by a poor passing attack, Oklahoma went completely away from the attack and took the focus off its defense, which struggled in pass coverage. Texas Tech finished with 393 yards in the air for the fifth time in the past seven games.
Oklahoma trailed by 14 points after the first drive of the second half but scored a touchdown on four straight possessions once the Red Raiders drove the field to open the second half.
The Sooners scored 35 of 38 points before Texas Tech threw a last-second touchdown pass.