No. 14 Oklahoma (1-2) had lost just once in September since 2009 but has lost twice in the first month of this season for the first time since 2005. The Sooners have now lost three of their past four games dating back to the 2016 College Football Playoff loss to Clemson.
Oklahoma's College Football Playoff hopes this year are all but dashed barely three weeks into the season.
On Saturday, the Sooners weren’t out gained by much by the Buckeyes, but Ohio State was able to take advantage of two Oklahoma turnovers and a handful of miscues by the Sooners. Ohio State (3-0) averaged more than 10 yards per carry through the first half, and Buckeyes receiver Noah Brown tied a program record with four touchdown catches – after just five career catches before Saturday.
The Sooners offense scored just one touchdown through the first 40 minutes and was saved in the first half by a 97-yard kick-off return touchdown by running back Joe Mixon, which should have been called back after Mixon dropped the ball before crossing the goal line.
Ohio State took an 18-point lead into halftime before scoring on the opening drive of the third quarter to take a 42-17 lead. The Buckeyes came into Norman as the highest-ranked visitor since Oklahoma beat No. 2 Texas, 65-21, in 2008. The Buckeyes left Norman with their 19th-straight true road win, which is a school record and the longest active streak in the nation. Ohio State has never lost a road game under Urban Meyer.
Oklahoma will be off next week before opening Big 12 Conference play against TCU on Oct. 1.
Mark Andrews, who took two big hits during the game, caught a touchdown pass with 4:06 to go in the third quarter, but after a defensive stop, Baker Mayfield was sacked on fourth down. Ohio State hit a field goal on the ensuing drive to ice the victory.
Mixon finished with 225 all-purpose yards as the Sooners averaged 5.1 per carry. Mayfield was 17-for-32 for 226 yards and two touchdowns. He moved into ninth all-time in total offense at Oklahoma.
Samaje Perine moved into eighth all-time in career rushing yards at Oklahoma.