Bradford suffered a concussion in last week's loss at Texas Tech. His status for this week's Bedlam game has been uncertain all week.
Oklahoma head coach Bob Stoops cleared it up on Thursday.
"Everything has checked out and barring any unforeseen circumstances, Sam will play this week," Stoops said.
A redshirt freshman, Bradford leads the nation in passing efficiency and is completing 70% of his passes. He's thrown 28 touchdown passes against just six interceptions and is just one TD pass shy of tying the NCAA record for a freshman.
Bradford has established OU records for passing yards by a freshman with 2,520 and consecutive pass completions with 22. He tied a school mark by throwing five touchdown passes against North Texas.
Oklahoma and Oklahoma State kick off at 2:30 p.m. Saturday on FSN.
If Oklahoma wins, it will claim the Big 12 South title for a second consecutive year and play Dec. 1 in the Big 12 championship game in San Antonio, Texas.