The sophomore also rushed five times for 18 yards to account for 324 yards of total offense.
Bradford has thrown four or more touchdowns in seven games this season including the last three in a row.
Lewis, a redshirt freshman linebacker, compiled a game-high 13 tackles, one for loss, one pass deflection and one pass interception, which hre turned 47 yards to set up the Texas Tech one. OU's DeMarco Murray ran in for a touchdown on the next play.
Lewis now has a team-high 118 tackles on the season, which is just 15 shy of the OU freshman record set by Brian Bosworth in 1984.
The Sooners close out the regular season this Saturday at No. 12 Oklahoma State. The game will be televised nationally by ABC with kickoff slated for 7 p.m.