It's flipped fortune, a mirror-image of a year ago.
Last year, Missouri was 11-1 and the No. 1 team in the Bowl Championship Series (BCS) standings.
The Tigers were riding the waves of a six game winning streak into the Big 12 Championship and were one win away from the national championship.
The Sooners this year, on the other hand, are full steam ahead, winners of their last six, and are presumably one game away from the national championship.
"Our goal has never changed," said senior wide receiver Juaquin Iglesias. "Last year, a two-loss team got to the National Championship game and anything can happen when you go week-in and week-out. Our goals have never changed. They were always to win a Big 12 Championship first and then whatever happened after that, we just wanted to go out there and win games."
Missouri, in contrast, has lost three of its last seven after starting the season 5-0 and is struggling to stay in the top 20.
When they could have gained momentum into this weekend's game by beating rival Kansas last weekend, the Tigers dropped the game when KU quarterback Todd Reesing completed a fourth down play for a touchdown in the waning seconds.
But despite the fact that the Tigers haven't had quite as successful season as many predicted at the beginning of the year, OU head coach Bob Stoops said not much is different in their team last year compared to this year and is preparing for them the same.
"Defensively, they have a veteran team back with a bunch of guys from a year ago," Stoops said.
In fact, the Tigers have only two starters on their defense that aren't upperclassmen.
They start no freshmen and have seven seniors on the starting depth chart defensively.
Offensively, there is a lot of talent, too.
"A bunch of great players are there," Stoops said. "Again, Chase Daniel, their quarterback, is a great player. He is so efficient running their offense. You can see that his mind is so quick, and he is so familiar with everything that they do that he can get the ball out fast and is very accurate. Then he has the ability to run and move around. He gives you a lot to deal with and he has a lot of targets to hit."
Many thought Daniel would be a sure show at the Heisman Trophy ceremony in December at the beginning of the season.
Maclin currently ranks 10th in the nation with 1,175 receiving yards and 11 touchdowns, and Coffman brings leadership.
"Jeremy Maclin is an incredible player at receiver and then Coffman, their big tight end, [is] another good player," Stoops said. "And they bring a good running game. Washington, their running back and a couple of more running backs do a good job of running the ball, more so than people talk about.
So, with all the talent, the Sooners aren't overlooking the mirror-image scenario.