The Jayhawks did their best to avoid it, as they leapt out to an early 16-6 lead, in large part due to both efficiency on the offensive end as well as the Sooners' inability to hit a shot.
But OU came storming back with a more focused offensive attack, using a 15-0 spurt that turned into a 31-8 run to close the first half.
"We were patient on offense," said OU junior guard Danielle Robinson. "We didn't try to do too much. In the beginning we were fumbling the ball a little bit, but [it changed] after that, and we took care of it."
The Sooners led at the intermission 37-24.
And didn't take long for them to open that lead further in the second half.
After the Jayhawks scored the second half's first points, OU went on another run, this time a 12-2 flurry that spanned 2:37 and opened up a 21-point lead.
KU, though, mounted a little rally of its own that forced a Sooner timeout midway through the second half, when it came back to within 11 points and a couple minutes later within 10 at 57-47.
But that was all the closer the Jayhawks would get, as OU's stifling zone defense prohibited KU from cutting it to single digits.
"We prepared for it this week and felt like it could be a weapon against them," Coale said. "They do a really nice job of getting to the interior of the zone, but it's mostly [Danielle] McCray. So we had just worked on having great awareness of where she was at all times and not really matching up with her, but in a sense, matching up with her until we could hand her off to somebody in another position."
OU once again extended its lead to near 20 points.
From that point on, the Sooners coasted to victory, winning their third straight and moving to 4-1 in Big 12 play and 14-4 overall.
Senior guard Nyeshia Stevenson led the way for the Sooners with 22 points on 7-for-16 shooting from the field, including four threes from behind the arc.
One of the bright spots was McFarland, who finished 5-for-6 from the field with those 11 points to go along with eight boards.
"I've felt for awhile that Jo's been on the path of breaking out," Coale said. "And she's been good for us. Overall she's been good. As a freshman, she's played significant minutes in very important games. But I felt like she could score a little bit [more than she has]. She had that opportunity tonight. I thought she handled extra passes, interior passes, extremely well and finished around the rim."
Norman-native and senior guard Sade Morris led the Jayhawks with 17 points throughout 29 minutes of playing time.
The Sooners next hit the road for a 7 p.m. Wednesday tipoff at Iowa State.