After falling down 15-2 and 17-4 early, it was all OU the rest of the way.
The Sooners surged on a 21-8 run to tie the game up at 25 at the 8:03 mark in the first half, and from that point on, OU never trailed again.
OU leaped out to a seven-point lead at 41-34 when senior forward Nyeshia Stevenson hit a jumper inside the arc, and the Sooners had a 43-39 advantage at intermission.
The Wildcats hit a free throw to open the second half, but they would never get closer than three points again throughout the remainder of the contest.
OU extended a 10-point lead at the 13:42 mark in the second half.
UK cut it back to eight within the final 10 minutes, but that's when the Sooners delivered the knockout punch.
The Sooners responded with a 13-2 burst to build a 19-point lead with six minutes left.
OU's advantage reached as much as 23 points on two different occasions on the way to a convincing 20-point win.
The Sooners dominated several aspects of the game, as they outshot the Wildcats 61.5 percent to 32.9 percent, outrebounded the ‘Cats 36-34 and won the bench points and fast break points 14-12 and 14-8, respectively.
OU was efficient enough on the offensive end when they did get shots up in order to overcome 21 turnovers.
Stevenson led the Sooners, tied for a game-high 31 with Kentucky's junior forward Victoria Dunlap, while senior forward Amanda Thompson had 17, and junior guard Danielle Robinson also finished in double figures at 16.
The Sooners are set to face the Stanford Cardinal at 6 p.m. Sunday in San Antonio in the National Semifinal Round.