The Rebels (3-5, 1-4) scored first after receiving the opening kickoff. On the second play from scrimmage, Jeff Scott raced 83 yards for a touchdown.
After the Tigers went up 14-7, their second score a 68-yard run by Onterio McCalebb, Ole Miss tied it on a beautiful catch of 29 yards by Markeith Summers from Jeremiah Masoli.
In the second period after Auburn got a field goal and got the ball back, the Tigers fumbled and the football was recovered by Jason Jones for the Rebels. But on second and 10, Masoli was intercepted, and the Tigers had it back at their own 2-yard line.
They proceeded to take it all 98 yards with Cam Newton passing to Darvin Adams for 24 yards and a touchdown.
Ole Miss got a 32-yard field goal by Bryson Rose on a 10-play drive that stalled. But the Tigers answered immediately without ever taking a snap. Demond Washington returned the Andrew Ritter kickoff 95 yards for a 31-17 AU advantage.
Ole Miss got the ball back and moved to its own 41 where on fourth and 1, Masoli was stopped short. The Tigers took over and were able to get a field goal of 35 yards by Wes Byrum right before halftime to take a 34-17 lead into the locker room.
Auburn added a 48-yard Byrum field goal early in the third quarter for a 37-17 lead and made it 44-17 on a 30-yard run by Michael Dyer. That's the way the third quarter ended.
In the fourth period with the outcome no longer in doubt, the two teams added points on both sides of the scoreboard - Auburn a touchdown and Ole Miss two touchdowns.
When it was all said and done, the Tigers left town, their No. 1 BCS ranking likely secure.
The Tigers domiated the stats just like they did the ballgame itself. They had 572 yards of offense to 407 for the Rebs. In the first down department, Auburn had 28 to Ole Miss' 17.
On the ground it was 343 for Auburn to 218 for Ole Miss. Through the air, 229 for the Tigers and 189 for the Rebels. Auburn had the ball 33:14 to Ole Miss' 26:46.
Jeff Scott had 134 yards on nine carries to lead the Rebels in rushing. Masoli was 20 for 33 with a touchdown and an interception. Melvin Harris had five receptions for 45 yards to lead the Rebel receiving corps.
Newton was 18 for 24 for 209 yards and two touchdowns. He even caught a pass, from quarterback Kodi Burns for 20 yards and a touchdown. Dyer had 21 rushes for 180 yards and a score.