The Lady Tigers will face No. 2 Tennessee, the top seed, in a semifinal Saturday night.
LSU led by 18 points early in the second half after holding Ole Miss to 17 first-half points. The Rebels then rallied with a 13-0 run that made the closing minutes interesting.
With LSU leading 46-44, Fowles missed two free throws with 1:12 left. Jada Mincy then made two free throws to tie the game. Erica White, who led LSU with 17 points, answered with two free throws with 48 seconds left to put LSU back on top.
Ole Miss guard Armintie Price missed a jumper with 20 seconds left. LSU controlled the rebound and White's layup pushed the lead back to four points.
Fowles had 11 points and 14 rebounds for LSU (25-6).
Fowles, the first player to post double-doubles in all 14 regular-season conference games, scored in double figures for the 24th consecutive game.
Price led the Rebels (21-10) with 12 points despite making only three of 15 shots from the field. Ashley Awkward, who was 5-for-22 from the field, and Alliesha Easley each added 10 points.
Ole Miss, the top-scoring team in the league with at 78.1 points per game, shot only 22.2 percent from the field in the first half and 24.6 percent for the game.
The Rebels led 15-12 following a 3-pointer by Carla Bartee, but LSU finished the half with a 17-2 run to lead 29-17 at the break. White had seven points in the stretch.
Awkward and Price combined were 5-for-22 in the first half, and the shooting problems continued early in the second half.
A jump hook by Fowles gave LSU a 40-25 lead less than 5 minutes into the half. Another basket by Fowles gave the Lady Tigers a 42-28 lead with 12:52 left, but they then went scoreless for more than 7 minutes while the Rebels broke out of their scoring slump with 13 unanswered points.
Ole Miss finally gained some offensive momentum midway through the second half. Back-to-back baskets by Easley cut the LSU lead to 8 points at 42-34 with 9:15 left to play.
A free throw by Price, followed by a jumper by Awkward, cut LSU's lead to 42-37. Danetra Forrest capped the 13-0 run by scoring with 6:33 left to cut LSU's lead to 42-41.
White ended LSU's scoreless stretch by scoring after a steal with 5:26 left.
UM comeback falls short at SEC hoops tourney
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