Chris Warren played all 40 minutes and led Ole Miss with a career-high 25 points, hitting seven 3-pointers. Dwayne Curtis returned to Auburn with a double-double of 13 points and 11 rebounds, his eighth double-double of the year.
Frank Tolbert scored 29 points and DeWayne Reed had 21, both career highs, to lead Auburn.
Quantez Robertson's 3-pointer from the right corner broke a 70-all tie with 1 minute left for the Tigers (11-5, 2-2 Southeastern Conference).
Eniel Polynice of Ole Miss (15-2, 2-2) then missed a 3 at the other end. Tolbert made four straight free throws and Auburn went 7-of-10 from the line over the final 39 seconds to keep Ole Miss from tying after twice pulling within three points.
Ole Miss was trying to match its 16-1 start in the 1925-26 season but fell short with yet another close one in the SEC. The Rebels' first four league games have been decided by a total of 10 points.
Reed had a career-high 20 points in Auburn's win over LSU on Wednesday night, and promptly topped that. He was 4-of-7 on 3-pointers and Auburn hit 10 of its 19 attempts from beyond the arc.
Tolbert was 9-of-11 from the field and 9-of-12 from the line. Lucas Hargrove added 10 points for the Tigers, all in the first half.
Auburn upsets Ole Miss
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