Oregon State (19-3, 4-0) has now won 11 in a row while Arizona State fell to 10-10, 1-3.
Wetzler allowed two hits, struck out eight, walked just one and lowered his ERA to a microscopic 0.59.
In 30.2 innings over four starts, he has posted 28 strikeouts, allowed just nine hits and two earned runs, and held opponents to an .091 average.
His 28th career victory moved him into a five-way tie with Mike Gorman, John Sipple, Jeff Post and Dallas Buck for second place on Oregon State's all-time win list. Ken Noble (30) set the record from 1975-78.
Wetzler and ASU starter Brett Lilek each entered the game with 3-0 records and sub-1.00 ERAs. Both teams had scoring opportunities but they matched zeroes through four innings before the Beavers broke through with a three-spot in the fifth.
Walks to Nick Rulli and Michael Conforto sandwiched around Andy Peterson's bunt single loaded the bases with one out. Everyone moved up a base on Dylan Davis's sacrifice fly to left field, and a walk to Kavin Keyes reloaded the bases. Gabe Clark then dropped a two-run single into short right field to give the Beavers a 3-0 lead and knock out Lilek.
Oregon State added to its lead in the sixth off reliever Eric Melbostad. Trever Morrison singled with two outs; running on the pitch, he scored all the way from first on Peterson's double to make it 4-0.
Senior reliever Scott Schultz pitched two hitless innings to close out the Sun Devils. It was Oregon State's second straight shutout and its eighth of the season. Oregon State pitchers have combined for 18 quality starts in 22 games.
Peterson doubled, singled, scored one and drove in a run and Morrison had two hits, scored once and stole a base to lead the offense. Davis was 0-for-2 and had his seven-game hitting streak snapped.
Saturday's probable Starters: OSU RHP Andrew Moore (2-1, 1.01) vs. ASU LHP Ryan Kellogg (1-2, 4.18)
Baseball: Beavs post 11th win in a row
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