Jeremiah Johnson racked up 203 yards of rushing on 12 carries and scored once to lead all runners in the game. His running mate LeGarrette Blount also had a touchdown on five carries for 30 yards.
Jeremiah Masoli was 8-for-14, 115 yards and a touchdown to Jeffery Maehl.
The Duck defense also got into the scoring act when Walter Thurmond III picked off a Lyle Moevao pass for a touchdown.
Place kicker Morgan Flint was good on all three of his field goal attempts of 38, 22 and 25 yards.
Moevao saved a rout when he hit Shane Morales on an 11-yard pass in the closing seconds of the first half. Moevao was 13-25, 177 yards, two touchdowns and an interception. Jeremy Francis also had a touchdown reception. Place kicker Justin Kahut was 1-for-2 in field goals with a success at 24 yards.
Oregon's total offense of 442 yards was made up of 252 yards of rushing and 190 yards passing. OS had a total of 218 yards offense in the first half.
Ducks Jump Out to 37-17 Halftime Lead
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