The BTN reported the news prior to Wednesday night's game. Woodyard watched the action from the bench in street clothes, with an immobilizer on the foot.
With only one regular-season game remaining and then the Big Ten Tournament next week, Woodyard's college career appears to be over.
The BTN gave no details on how the injury happened.
Woodyard started 18 of the Nittany Lions' first 29 games this season. He is the team's third-leading scorer (8.7 ppg).
During his weekly press conference Monday, first-year Penn State coach Pat Chambers talked about Woodyard.
"Cammeron's given everything he's got," Chambers said. "He's playing to exhaustion. And that's what you want a senior to do."
Sunday's regular-season finale against Michigan at the Jordan Center will be Senior Day for Woodyard. Junior Billy Oliver, who decided to give up the sport due to recurring head injuries, will also be honored.