Sophomore quarterback Tino Sunseri, making his first career start at home, completed 24-of-34 passes for 275 yards, with two touchdowns, and one interception.
Ray Graham returned to action, and was able to find his way to 115 yards on the ground, with two rushing scores, including a 64-yarder in the fourth quarter, that capped the scoring for the Panthers. He split carries with Dion Lewis, who rushed 10 times for 27 yards.
Pitt was without starters Greg Romeus and Dom DeCicco, as well as Andrew Taglianetti. Left guard Chris Jacobson also went down with an injury in the first half, and did not return. He was replaced by Ryan Turnley at left guard.
In Romeus' place, Brandon Lindsey finished with two sacks. Chas Alecxih, in just his second career start at defensive tackle, led Pitt with three sacks. Overall, Pitt limited the Wildcats to 73 rushing yards on 35 carries.
We'll have more from Heinz Field, including reaction from coaches and players, later this afternoon.