Romeus (Coral Springs, Fla./Coral Glades) is scheduled for surgery on Thursday.
"Our top priority is doing what is best for Greg," Wannstedt said. "After consulting with him, his family and our medical staff, it was determined that immediate surgery is the best option for Greg both personally and athletically. We expect him to have a full recovery and return for the conclusion of the season."
A preseason All-America candidate and the reigning Big East Defensive Player of the Year, Romeus started the season opener at Utah and had four tackles and a pass deflection. He did not play in the Panthers' game last weekend against New Hampshire.
As a junior last season, Romeus was a unanimous first-team All-Big East selection after collecting 43 tackles, 11.5 tackles for loss and a team-high eight sacks. He additionally had three forced fumbles, an interception, a fumble recovery and blocked PAT.
Romeus was named a finalist for the 2009 Ted Hendricks Defensive End of the Year Award and was selected to three different All-America teams, including CollegeFootballNews.com (second team), Sporting News (third team) and Rivals (third team).
Pitt (1-1) has an open date this week. The Panthers return to action on Thursday, Sept. 23, when they host the Miami Hurricanes (1-1) for a national ESPN telecast at Heinz Field. Kickoff is set for 7:30 p.m.