Pitt is now 0-3 in Big East play, and suffers its fourth consecutive loss--the first four-game losing streak of the Jamie Dixon era.
Brandon Young scored 26 points, including a three-point play with 1.3 seconds left, as DePaul beat Pittsburgh 84-81 Thursday night.
Young scored the game's last seven points for the Blue Demons (10-4, 1-1 Big East) after Pitt (11-5, 0-3) held an 81-77 lead with 17.2 seconds remaining. Young's layup cut the Panthers' lead to two points; then Pitt's Isaiah Epps missed two free throws.
Young drove through the Panthers' defense for a basket and he was fouled with 1.3 seconds left. He made the free throw for a one-point lead, then Pitt threw the inbounds pass away. Young was fouled and made two more free throws.
Cleveland Melvin scored 20 points and Moses Morgan added 13 for DePaul, which before Thursday had won just two regular-season Big East games since 2008-09.
Talib Zanna had 16 points and eight rebounds and Ashton Gibbs finished with 13 points for Pittsburgh.