Nova suffered a concussion Saturday in a 28-10 victory over Eastern Michigan, but returned to practice on Tuesday.
"They're both getting reps the way they always would in a game week," Flood said on Nova and center Betim Bujari. "In these kinds of situations, I don't know if you ever know for sure until game day, but I'm very optimistic, I guess I would say right now, that both of those guys will play for us."
Nova was limited in practice Tuesday and did not practice Sunday after his injury.
During his rehab, the multi-year starter and team captain has done everything in his power to get better.
"I've been checking on his progress all the time and he's getting better each day," said junior guard Kaleb Johnson, who is Nova's roommate. "It's good having him back in the huddle and hearing him call the plays.
"He's doing all of the little things to try to get back. He's staying away from loud noises and bright lights and everything."
Senior Chas Dodd remains the choice to play if Nova has any setbacks.
Dodd worked with the first team on Sunday and continues to prepare as if he will be the guy.
"I feel game ready," Dodd said. "Obviously we still have a few more days and I'm just going to be repping this playbook and game planning and learning it and making sure I have everything down and just preparing myself the best way that I can."