Saint Louis, which had a two-game win streak snapped, fell to 14-11 overall and 5-6 in A-10 play. The 88 points allowed was the most in a game this season, topping the 81 points Kent State scored back in November.
Lisch matched his scoring output from the Xavier game by making seven of 12 shot attempts, including three 3-pointers, and knocked down eight of nine free throw attempts.
Brown had season highs of 19 points and eight rebounds in 30 points. Eckerle tied his season high with 13 points in 31 minutes. Brown and Eckerle each made three 3-pointers.
SLU trailed 41-36 at halftime — which was more total points scored than in the 49-20 loss at George Washington — and was outscored 47-41 in the second half.
UMass (16-9, 5-6) was led by 21 points from Dante Milligan.
The Billikens host Fordham on Wednesday at Scottrade Center.