The Green Knights entered the game ranked No. 1 in the state and with a 17-game win streak. But instead of playing for their second state championship in three seasons, Mitchell and Co. headed home without a trophy.
Mitchell finished with a game-high 24 points on eight-of-19 shooting, to go along with six rebounds, two steals, two assists and a blocked shot before fouling out.
Aquinas jumped out to an early lead before Dominican rallied.
"As me being the senior, I'm one of the big leaders on the team," Mitchell told reporters after the game. "When we got down, I told some of my guys don't worry about it. Down in Minnesota we did the same thing and we came back. But I guess Aquinas, when we started pressuring up, they handled it."
The Green Knights took their only lead, at 46-45, with 7:07 left in the fourth quarter. But Aquinas outscored Dominican 22-13 the rest of the way.
"I don't know what happened after that," Mitchell said.
Dominican went 24-2 on the season and won the Midwest Classic Conference championship. Mitchell, who missed time early in the season with an injury, averaged a team-best 15.8 points per game.
Mitchell averaged 19.3 points per game as a sophomore and 16.4 points per game as a junior. He led the Green Knights to a 21-4 record and a Midwest Classic Conference championship.