Katie Paganelli added 13 points and Lauren Woods collected a team-high seven rebounds, including six on the offensive glass as SLU (4-8) tied its season high with 19 offensive boards. The Bills earned a 34-28 overall rebounding advantage.
After a Heather King layup put Saint Louis on top 13-12 with 10:56 to go in the first half, Colorado (5-4) constructed a 10-0 run fueled by consecutive 3-pointers from Brittany Spears and Bianca Smith.
The Billikens received their own consecutive treys from Paganelli and Lisch to slice the CU lead to 24-19, but the Buffaloes went on a 16-4 scoring binge over the final 7:17 to take a 40-23 lead to the locker room.
Colorado expanded its cushion to 26 points, 53-27, with 12:50 remaining. Lisch then scored 13 of her 21 second-half points, including a driving layup that put her above the 1,000-point plateau, in a 28-14 run that narrowed the CU margin to 67-55 at the 2:26 mark. But Spears' 3-pointer on the Buffaloes' next possession slowed the Billikens' momentum.
The teams combined to shoot 57 free throws, with Saint Louis converting 22-of-28 for 78.6 percent and Colorado netting 25-of-29 for 86.2 percent.
The Buffaloes shot 61.9 percent from the field in the first half and finished at 52.3 percent, while the Bills shot 35.2 percent for the game.
Spears led Colorado with 21 points and was joined in double figures by Smith (16), Kara Richards (15) and Alyssa Fressle (11). Smith and Fressle had game highs of eight rebounds and five assists, respectively.
The Billikens host No. 5 Oklahoma Tuesday, Dec. 30, at 5:30 p.m.