Lisch's scoring performance also was a Tom Gola Arena women's record and the top output by any player, women or men, in the A-10 this season.
She registered career highs in field goals made (12-of-19) and 3-point field goals made (6-of-7) and was 7-of-7 from the foul line. Lisch, who raised her season scoring average to 20.5, eclipsed the previous SLU standard of 35 points she shared with Kate Hart and Kelly George.
Alisha Goodwin registered 12 points and four assists, and Amanda Kemezys added 10 points, seven rebounds and three steals. Heather King had nine rebounds and Lauren Woods grabbed seven boards for SLU, which registered a 43-30 advantage on the glass including a season-high-tying 19 offensive rebounds. Janisha Gearlds collected four assists.
Saint Louis led by 13 at halftime and owned a 54-38 cushion after Goodwin scored a driving layup with 9:42 left. La Salle (9-9, 0-3 A-10) then went on a 13-0 spurt, including 3-pointers on three consecutive possessions, to slice the Billiken lead to 54-51 at the 6:18 mark.
Following a timeout, Lisch caught a pass coming around a screen and nailed a 3-pointer from the right wing to slow the La Salle momentum. She was fouled on the shot and converted the rare four-point play, then hit a 17-footer in the key on the Bills' next possession to put SLU on top 60-51 with 4:55 left.
The Explorers then assembled another run, this one an 11-0 flurry, to claim their first lead since holding an early 5-4 edge. Jamie Walsh, who was 6-of-11 from 3-point range and scored a team-high 24 points, connected on two treys during the outburst, the second putting La Salle on top 62-60 with 2:23 remaining.
Lisch answered again, calmly sinking a 3-pointer from the left wing to restore the Saint Louis lead. Goodwin followed with two free throws after a defensive stop, and SLU was up 65-62 with 1:34 to play.
The Bills caught a break when Jenna Gilbert's 3-point try rattled in and out. Two possessions later, Lisch sank both ends of a 1-and-1 with 22 seconds left for a 67-62 Saint Louis margin.
Margaret Elderton made it a one-possession game with a driving layup with 12.8 seconds left. The Billikens missed an opportunity to put the game away in regulation by missing the front end of a 1-and-1 on their next possession, and Walsh sent the game to overtime by netting a trey with one tick remaining.
La Salle twice held a two-point lead in the extra session, and the Explorers had the ball with a chance to expand the lead on the second occasion. They failed to convert, however, and Lisch made them pay with her sixth and final trifecta that gave the Billikens a 72-71 edge at the 1:56 mark.
Morgan Robertson beat the shot clock with a bank shot that put La Salle back in front. The Billikens misfired on their next possession, but King was fouled on the rebound and made the second of a two-shot foul to knot the score at 73 apiece with 1:08 left.
Following a strong defensive stop that forced La Salle to take a bad shot, Lisch tied the school record by sinking a 17-foot jumper for what proved to be the winning points. Elderton just missed a driving layup that likely would have sent the game into a second overtime, but Lisch grabbed the rebound, was fouled and broke the school scoring mark with two free throws that sealed the win.
In the first half, SLU showed balance in jumping to a 17-10 lead at the 11:09 mark. Six Billikens scored during that stretch, led by Lisch's five points and King's four points.
After La Salle scored the next five points on a Walsh 3-pointer and two free throws by Morgan Robertson, the Billikens embarked on a 17-6 flurry to conclude the half. King ignited the run with an offensive rebound and layup, and Kemezys duplicated that on SLU's next possession. Kemezys followed with another layup, and Lisch buried a trey in transition that gave the Bills their first double-digit advantage, 26-15, with 3:50 left.
The Explorers narrowed the gap to 28-21 with a pair of 3-pointers, but Saint Louis tallied the last six points of the half. After Woods drove the baseline for a layup, Lisch hit a 17-footer in the key and made a driving fast-break layup at the buzzer to give the Billikens a 34-21 halftime cushion.
The Bills shot 50 percent (14-of-28) in the second half and overtime combined and finished the game at 45.2 percent. La Salle was an ice-cold 7-of-29 (24.1 percent) in the first half before connecting on 17-of-25 attempts (68 percent), including 8-of-14 (57.1 percent) from beyond the arc, in the second half to finish at 45 percent.
Saint Louis continues its road trip Tuesday at Charlotte. Tip time is scheduled for 11 a.m. (CT).