San Jose State (6-5, 2-0) led 44-38 at halftime thanks to five three-pointers, including a pair by Williams and Jessica Kellogg.
Dragana Zoric kept UTEP in the game in the first half, going 10-for-11 from the field and scoring 21 of the Miners' 38 points. Zoric's hot hand also helped the Miners shot 57 percent in the first period of play.
UTEP opened the second half with a bucket and then a three by Angie McGee to cut San Jose State's lead to 46-43.
However, the Miners went south after the first two minutes of the second period.
San Jose State then pulled away a runs of 8-0 and 12-0, and saw its lead grow to 21 (71-50) at the 6:42 mark.
UTEP shot 32 percent in the second half and turned the ball over 21 time on the game.
Zoric finished as UTEP's only player in double figures, closing with 23. She also had a team high six assists and four steals.
SJSU's Williams added 12 assists and three steals to go with her 22 points. Kellogg also chipped in 16 in the effort.
Unlike UTEP, the Spartans were able to string two consistent halves together, shooting 52 percent in the first period and 54 percent in the second frame.
"It was a great game and we played a solid second half," noted Spartan head coach Janice Richard. "We stepped up defensively, scored 27 points off turnovers and played great transition basketball. Its nice to go 2-0 to open conference play."
San Jose State's Williams was able to check Zoric in the second half, holding her to just two points in the second half.
"Cricket did a good job guarding Zoric. Especially since I asked my point guard to guard a forward," added Richard. "She was able to really limit her on touches and in 13 minutes, she really had just one good look."