Clarkson hit 9 of 14 fields goals, including 3 of 4 3-point attempts, for the Golden Hurricane (13-9, 6-2 Conference USA), who won their sixth straight game. Scottie Haralson added 17 points, and Eric McClellan had 10.
Robert Nyakundi had 18 points and Leslee Smith 10 for SMU (10-11, 2-5).
The Mustangs grabbed their only lead of the game when Jalen Jones converted a three-point play and London Giles followed with a jumper to put SMU ahead 40-37 with 16:28 remaining. Clarkson responded with a layup and McClellan hit a 3-pointer to spark an 8-0 run that put Tulsa back on top for good.
SMU pulled within 58-54 with 1:54 remaining, but Clarkson hit a 3-pointer and then scored on a fast-break dunk to put the game out of reach.