Southern Miss was able to respond with a field goal of their own early in the second quarter to knot things up with the Tigers at three.
Memphis took back the lead on their next drive with another field after a big goal line stand by the Eagles.
Southern Miss marched the ball down the field with ease on their next drive. Damion Fletcher punched in a one yard score for the first touchdown of the game to make it a 10-6 game in USM's favor going in to halftime.
Tracey Lampley showed off his explosiveness in the second half with USM's first punt return for a TD since 2003. It was Lampley's first Touchdown return of his career.
"I just got to thank the guys out there blocking for me allowing me to catch the ball and make some plays" said Lampley.
After a big Freddie Parham return, the Eagles had no trouble punching it in to extend their lead to 30-9.
Memphis responded with their first touchdown of the game, only to have Deandre "Touchdown" Brown get his first TD reception of the game and make the score 36-16.
That score would hold up until the final buzzer to give the Eagles the 36-16 win over the Tigers.
"I tell you what, it is good to be back on that side of the column" said Head Coach Larry Fedora.
Southern Miss' stats won't blow your mind, but no one will argue that this was their best overall game of the season so far. "I think that was the most complete game that we played" said Fedora "We still had mistakes, but it was the best game as far as all three phases are concerned."
Damion Fletcher led the team in rushing with 67 yards on 17 carries followed by Tory Harrison with 55 on 13 carries.
In Martevious' second career start, he was 10-21 passing for 155 yards, a touchdown, and an interception.
Deandre Brown had another solid day with five catches for 83 yards and his second touchdown reception of the year.
Special Teams was where Southern Miss dominated the night, though. Tracey Lampley returned a 50 yard punt for a touchdown and Freddie Parham had another big night returning kickoffs with a 78 yard return.
This win broke a three game losing streak for the Eagles and makes the undefeated at home and winless on the road.
They will take on their bitter rival, the Tulane Green Wave, in the Battle for the Bell next Saturday. This will be the Homecoming game for Southern Miss.