Their rivalry has left games to remember throughout men's basketball history.
What is even better for fans of the sport is that this rivalry of tradition will continue despite what the Big East Conference is becoming, as both the Orange and the Panthers will be moving together to the Atlantic Coast Conference (ACC).
In their final regular season match before that move, here is what you need to know about the Panthers:
1. Their top scorer: Junior forward Talib Zanna
Zanna is atop all Panther players with 11.2 points per game.
However, consistency arises when talking about Zanna, as he has only scored in double-figures in half of Pittsburgh's game (11 of 22).
In the last six Big East contests for the Panthers, Zanna has been quieted, failing to reach the double-digit mark. All were unranked opponents outside of the Louisville Cardinals, against whom he had four points.
2. Mr. Right Now: Junior forward Lamar Patterson
Patterson is the only member of the Panthers to have scored in double-figures consistently in the team's most recent match-ups.
In the last four Big East contests for Pittsburgh, Patterson has recorded no less than 10 points. The Panthers went 3-1 within those four games.
Patterson is averaging 10.2 points per game and has surpassed season-leading scorer Zanna in most games in double-figures with 13.
3. Aiding others:
The Panthers are currently sixth in the nation in assists per game with 17.5.
Syracuse sophomore guard Michael Carter-Williams' drop in assists per game from 10 against non-conference opponents to seven versus the Big East places them below Pittsburgh, with 15.8.
Senior guard Tray Woodall leads Pittsburgh with an average of just under six assists per game.
In three of the last four matches for the Panthers, Woodall has provided no less than six helpers. Pittsburgh won all of those games.
4. On the glass:
Tied for last place in the Big East, the Panthers average a little over 22 rebounds per game on the defensive end.
Offensively, they gather 13.5 rebounds per contest, the fifth-best total for Big East programs so far, trailing conference-leading Syracuse by less than two offensive rebounds per game.
Overall for the season, Pittsburgh has the advantage over their opponents by almost 10 rebounds per game, on average.
Attacking the glass the most are freshman center Steven Adams and Zanna, both with about six rebounds per game.
5. In the Petersen Events Center:
Pittsburgh is 12-2 at home this season.
But none of those 12 wins have come against a ranked opponent.
The Panthers are 0-2 at home since their 12-0 home start.
Both losses have come to Big East opponents, meaning that the Panthers are currently winless on their home court against conference opponents this season.