Sophomore center Chinanu Onuaku led Louisville with 13 points while tying a career-high 15 rebounds (seven offensive). He also added four assists.
Senior guards Trey Lewis and Damion Lee were terrific all night for the Cards. They finished with 14 and 15 points, respectively. Their pressure defense caused fits for the Orange all night, which ultimately led to 11 turnovers.
The Cardinals handled the Orange on the glass, 41-30; fourteen came on the offensive end, which led to 17 second-chance points.
After getting out to an early 18-6 lead, Louisville outscored the Orange 66-40. Trey Lewis hit a 3-pointer at the end of the first half to give the Cardinals a 28-27 lead. It looked as if Syracuse was heading into the locker room up two at halftime, but instead trailed by one.
The most concerning stat of the game was points in the paint. Louisville finished with 50 points in the paint to SU's 20. After Dajuan Coleman picked up his second foul early in the first half, Tyler Lydon was forced to play the five. Onuaku, who had arguably his best game of the season, manhandled him. Lydon finished with six points, seven rebounds and three turnovers in 31 minutes. He was undersized the entire night.
Malachi Richardson finished with 10 points on 2-of-9 shooting, 2-of-6 from 3-point range. It was Richardson's worst game since his 4-for-20 (0-for-11) performance at Madison Square Garden against St. John's.
Michael Gbinije seemed off all night despite scoring 13 points, grabbing seven rebounds and dishing out five assists. He committed three turnovers and seemed bothered by Louisville's pressure all game. The weakness in Gbinije's game is his ball handling, and going up against a pesky Cardinal squad isn't exactly ideal.
Tyler Roberson also struggled Wednesday night. He scored five points and corralled four rebounds in a quiet game for the junior.
Trevor Cooney and Frank Howard were the two bright spots for the Orange offensively. Cooney finished with a game-high 19 points on 6-of-14 shooting, 5-of-10 from deep. Howard dished out six assists and only had one turnover.
As a team, SU went 12-for-21 (57%) from charity stripe and 8-for-24 (33%) from 3-point range.
They fell to 18-9 overall, 8-6 in ACC play.
The Orange return to the floor on Saturday vs. Pittsburgh (18-7, 7-6). Tip off is scheduled for 2:00 p.m. ET on ESPN2.