The win was also a coming out party for Billy Edelin, who contributed a game-high seven steals. Edelin, who sat out much of last year because of personal reasons, had been used sparingly up until Monday.
But Edelin played a key role in the win adding five assists and four points to his game total.
Torin Francis had 15 to lead the Irish.
Boeheim wins 300th in victory over Irish
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