McNeil sent away two shots at the conclusion of the first half, including an emphatic swat as time ran out.
"If people challenge him," Boeheim said, "he's going to block shots."
Carmelo Anthony added 24 points and 11 rebounds, his fifth such game, and senior Kueth Duany scored 19 as the Orange won their fifth straight. Syracuse had beaten Binghamton in their first meeting last year, 103-56.
"They played harder than any team we've played all year long," Duany said.
Syracuse shot 58.8 percent as Josh Pace and Craig Forth added 10 points apiece. Hakim Warrick collected 16 points and nine rebounds.
Binghamton center Nick Billings scored just eight points and only had one block before fouling out after playing 18 minutes. The Bearcats had an early 3-2 lead before the Orange opened up a 38-17 lead and then went on a 14-2 run to claim a 52-36 halftime lead.
The Carrier Dome fell quiet after Anthony crashed to the floor with 18 minutes left in the second half. He rolled over in pain several times before being helped off the floor. Anthony returned three minutes later before draining a shot to put the Orangemen up 16.
"Our defense is playing better," Anthony said. "Whoever is getting double-teamed has the confidence in the other players to hit the shot."
McNeil, Syracuse beat Binghamton
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