Syracuse (11-2, 2-1 Big East) had its 11-game win streak snapped, while Pitt started 14-1 for the second straight season, improving its record to a Big East best 4-0.
Knight, a third-team All-American point guard, had to leave the game after colliding with Syracuse's Craig Forth early in the second half. Still, the Panthers proved they could win without their playmaker, going inside to Troutman, who hit 10-for-12 benefiting from shoddy Syracuse defense.
Outside, Page hurt the Orangemen nailing 10-of-15 from the field, including 4-of-8 from downtown.
After Knight left the game, Pitt went on a 13-5 run to open up a 50-40 lead, after trailing by as many as seven in the first half. Jaron Brown shot just 2-of-11, but did the job defensively, holding Carmelo Anthony to 14 points. Anthony came in averaging a conference-best 23.5 points.
Gerry McNamara led Syracuse with 19 points and Hakim Warrick added 11 points and 10 rebounds.
The loss also marked the return of Syracuse point guard Billy Edelin, who had been suspended for all of last year on sexual misconduct allegations and then another 12-game suspension following his participation in a recreational league.
Edelin, a highly-touted recruit, played just five minutes and hit a meaningless layup in the closing seconds of the game.
Pitt, Page, down Cuse
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