James was the Frogs leading rusher through two games, rushing for 168 yards on only 17 carries. He led the Frogs ground attack with 99 yards against the Jayhawks.
James, a Doak Walker candidate, returned as the Frogs leading rusher prior to the 2012 season, rushing for 875 yards in 2011.
TCU head coach Gary Patterson at his press conference on Tuesday told reporters that James would be a game time decision for the Frogs, who host Virginia at 11AM this Saturday. James injured his knee on a 16-yard run against the Jayhawks and James immediately clutched his knee. However, the junior was able to walk off the field under his own strength after being looked over by the trainers.
The Frogs now have seniors Matthew Tucker and Aundre Dean along with true freshman B.J. Catalon to carry the running game. Tucker, also on the Doak Walker watch list, has nearly 2,200 yards and 27 touchdowns in his career; he's rushed for 100 yards in 2012, including 65 yards last week at Kansas. Catalon has added 63 yards and Dean has 29 yards.
Since James has played in less than 30-percent of the Frogs' games, he will be eligible to apply for a medical redshirt and have two years of eligibility left once he returns for the 2013 season.
It's another big blow for the Frogs who have lost several key contributors this season due to injury. Defensive end Ross Forrest, linebacker Danny Heiss, cornerback Travoskey Garrett and tight end Stephen Bryant were lost to injuries prior to the season.