Terry Henderson scored 17 for the Mountaineers as they left Fort Worth with a 63-50 victory.
Sophomore point guard Kyan Anderson led the Frogs with 16 points.
TCU head coach Trent Johnson said the game came down to toughness.
"It's pretty simple. Physically and mentally they are a lot tougher than we are," Trent Johnson said. "Huggs has always been a guy that challenges his players from a physical and mental toughness standpoint."
"It's hard right now for us because we can't simulate that kind of opponent in practice. That's on me," Johnson said about the toughness of the Mountaineers.
"I'm beside myself right now because I'm all about what West Virginia is, physical and tough. I just can't wait ‘til we get there."
The Frogs shot well in the first half and outrebounded the Mountaineers 17 to 5. However, 11 turnovers and 11 fouls spoiled what was otherwise a solid half for the Frogs.
Sophomore Jabarie Hinds hit a three pointer at the buzzer to give West Virginia a three point halftime lead.
After shooting 60 percent in the first half, the second half was not nearly as kind to the Frogs.
Hinds scored seven of his 12 points in the second half as Bob Huggins' Mountaineers held TCU to 25 percent shooting from the floor.
?West Virginia coach Bob Huggins said his team went zone to slow the TCU offense.
"We went 2-3 zone because they were coming down and attacking us," Huggins said. "We tried to burn some clock and make them not just be able to come down and attack right at us."
Saturday was Huggins' 1000th game and 199th at West Virginia.
"I'm not going to get unhappy when we win. I'm going to get us some BBQ, get on that plane and turn around on Tuesday and come back to Waco. We are going to fly 31,000 miles. That's one and a quarter times around the world," Huggins said.
At TCU, Trent Johnson coached his 23rd game, and his Frogs fell to 1-9 in Big 12 play.
The Frogs failed to maintain the momentum from knocking off Kansas earlier in the week.
"The thing that bothers me is regardless of what happened in the past, when you prepare and know how physical a team can be and don't respond to that, that's a problem," Johnson said.
The Frogs return to the court Monday to take on the Oklahoma Sooners in Norman.