The game will be televised live at 6:30p.m. on FOX Sports Southwest.
Friday's game marks the 189th meeting between the Frogs and Mustangs. SMU holds the series edge 103-85 and won last season's game 64-61.
SMU returns all five starters from last season's 15-17 team.
The Frogs are expected to start two true freshmen against SMU; center Karviar Shepherd and Hudson Price. Shepherd scored 16 points last Friday in the Frogs 81-74 exhibition win over Arkansas-Fort Smith.
Senior Jarvis Ray is also back after a season-ending injury last season.