The Lady Volunteers (19-5, 10-1 Southestern Conference) shot a scorching 59.4 percent from the floor and piled up 23 assists.
Meighan Simmons (24), Bashaara Graves (19), Nia Moore (12), Taber Spani (12) and Kamiko Williams (11) paced Tennessee in scoring.
Diara Moore's 16 points were a team high for Ole Miss (8-15, 1-9).
The Lady Vols carried a 40-27 advantage into the half. They knocked down 93.8 percent of their free throws.
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