Tennessee shot 54 percent and, despite 22 turnovers, had an easier time against the Colonials (1-1).
Tennessee led from the beginning as George Washington struggled to get good looks at the basket, shooting just 10-of-27 from the field in the first half.
Tennessee stretched a 21-point lead at halftime to 29 on Jackson's basket with 16:18 left, but George Washington started to carve into the lead.
Michaela Leary hit a 3, and Erica Lawrence made a basket and a 3-pointer to start a 16-2 run, capped by Liz Dancause's 3 that cut it to 63-48 with 12 minutes remaining. Tennessee coach Pat Summitt called two timeouts during the spurt.
After the second timeout, Jackson ended Tennessee's five-minute scoring drought with a three-point play. Lawson stole the ball from Cathy Joens, leading to another basket by Jackson, and Loree Moore hit a jumper to stretch the Lady Vols' lead back to 20 with 8:50 to go.
Jackson hit a jumper and a driving layup, followed by two straight 3-pointers by Brittany Jackson to give the Lady Vols a 19-point lead with 11:42 left before halftime.
The Lady Vols continued to battle after they led by 25. Moore turned away from the player she was defending to swipe the ball away from Anna Montanana. Moore passed to Tasha Butts, who found Gwen Jackson streaking to the basket for a 46-19 lead with three minutes remaining in the first half.