Tennessee (6-1) handed Louisiana Tech (2-2) its first loss at home in 22 games. Trina Frierson had 12 points for Louisiana Tech - whose previous low was 44 points in the 1986-87 season.
It was the home debut for Kurt Budke, who this season replaced Leon Barmore as the Techsters' coach.
Tech's worst previous loss at home was Tennessee's 19-point victory in 1998-99.
The Volunteers held the Techsters to 20-percent shooting. Tech made only 1-of-9 from 3-point range and was outrebounded 55-36.
Tennessee shot only 40 percent, but made six of 13 3-pointers. Kara Lawson and Shana Zolman added 11 points each for the Vols, and Ashley Robinson grabbed 12 rebounds.
Amisha Carter added 10 points for Louisiana Tech, which trailed 41-14 at halftime.
The Techsters, who have eight new players, including five freshmen, immediately showed their youth against the Vols. The Techsters shot only 15 percent in the first half (6-of-39) and missed all six of their free throws.
Even the experienced Tech players had trouble against Tennessee. Cheryl Ford, the Western Athletic Conference player of the year last season, was just 1-of-9 from the field. She had seven rebounds.
Tech and Tennessee are the winningest teams in women's college basketball, and the only two teams to participate in all 21 NCAA tournaments.
The Techster program is 296-18 at home, but Louisiana Tech hasn't beaten Tennessee in Ruston since the 1996-97 season.