Jackson shot 13-of-18 from the floor, including 2-of-3 from 3-point range and made her four free-throw attempts for the Lady Vols (14-3, 3-0 Southeastern Conference).
Shanna Zolman added a career-high 19 points for Tennessee, which shot 52 percent for the game and built a 52-17 halftime lead.
Tishona Gregory and Bernice Mosby had 12 points each, while Sarah Lowe added 10 for the Gators (8-8, 0-4, who lost their fourth straight game.
Zolman was 7-of-12 shooting for the Lady Vols, including 4-of-5 from 3-point range. Tennessee finished 11-of-16 from beyond the arc, and outrebounded Florida 53-31.
The Gators, who started four freshmen and a sophomore, made just seven shots in the first half and finished shooting 32.8 percent.