The Lady Rebels got as close as nine points in the first half, but a 12-0 run early in the second half ensured a blowout.
Jackson started the run with a putback and finished it with a three-point play for a 25-point lead with 12:35 remaining. She drove to the basket, and the ball rolled off her hand as she was suspended in the air above the Ole Miss defenders.
Soon, the reserves were back on the court. Shanna Zolman's 3-pointer with 3:46 left gave the Lady Vols a 77-37 lead.
The Lady Rebels (12-9, 1-7), led by Amber Watts with 14 points and eight rebounds, have lost 10 straight games to Tennessee.
Reserves Shyra Ely and Tye'sha Fluker scored 10 points apiece for Tennessee, which had a season-high 61 rebounds. Ole Miss had just 32 rebounds.
All 11 Tennessee players had at least three points and one rebound.
Tennessee started the game with a 12-2 run. But coach Pat Summitt began taking the starters out with about 10 minutes left before halftime.
All of the starters were on the bench with five minutes to go, and the Lady Vols' 17-point lead dwindled to nine.
Carletta Brown had a driving basket to start a 9-1 run by Mississippi, capped by Genice Terry's 3-pointer that trimmed the lead to 28-19 with four minutes remaining in the first half.
After a timeout 20 seconds later, Summitt left the reserves in, and they pushed the lead back to 12 at halftime.
Neither team shot more than 33 percent in the first half. Midway through the half, Tennessee was 8-of-27 from the floor while Ole Miss was 4-for-18.