Louisville broke on the board with an unearned run in the second for a 1-0 lead. UT's Alex Suarez tied the game with a sacrifice fly in the sixth.
Scott Barber (3-0), Louisville's No. 1 pitcher, picked up the win in seven innings of work. He allowed one unearned run on six hits with three strikeouts.
In an apparent effort to save its starting pitchers for this weekend's three-game series with Miami, Tennessee used seven relief pitchers in the game. Starter Patrick Green gave up one unearned run on three hits in two innings. He struck out four and walked one. Beau Massey pitched 1 2/3 innings and was followed by Dusty Johnson for 1 1/3 innings and John Parscal for 2/3 of an inning.
Joey Andrews (0-1) was next and was saddled with the loss, although he struck out three in 1 2/3 innings. Steve Wesley came on in relief of Andrews and gave up the go-ahead run and four more in the ninth before Brandon Crowe came on to get the final out.
Javi Herrera had two of Tennessee's eight hits.