The Aggies built a 24-14 halftime lead, extended that lead to 38-14 in the third quarter, then cruised to victory.
Texas Tech got an early 7-0 lead but the Aggies came back with Ryan Tannehill completing 24 of 31 passes for 277 yards and 3 TDs in the first half as the Aggies built a 24-14 first half lead.
Texas A&M took its first lead of the game, 10-7,early in the second quarter with Tannehill tossed a 3-yard TD pass to tight end Michael Lamothe, culminating a 7-play, 70-yard drive, extending the Aggie lead to 17-7.
On the Aggies next possession, it took just 4 plays to move 57 yards, with Tannehill throwing a 6-yard TD to Jeff Fuller.
After Tech pulled back to within 3, 17-14, the Aggies drove 60 yards in 8 plays in the last minute of the first half, and Tannehill connected again with Fuller, this from 2 yards out with 9 seconds left in the half to give the Aggies a 10-point halftime lead, 24-14.
Critical to the game and the Aggies' first half lead were two forced Tech fumbles recovered by the Aggies in the endzone for touchbacks.
Two Cyrus Gray touchdown runs in the third quarter gave the Aggies a commanding 38-14 lead.
Tech scored two meaningless fourth quarter touchdowns to make this game look closer than it really was.
In securing a 45-27 win, Texas A&M outgained Texas Tech in both yards, 623 to 452, and in first downs, 35 to 24.
Many of Tech's yards, 179, came after A&M had built a 38-14 lead.
Ryan Tannehill completed 36 of 50 passes for 449 yards and 4 TDs. Jeff Fuller caught 11 passes for 171 yards and 2 TDs. Ryan Swope caught 7 passes for 105 yards. Cyrus Gray rushed for 102 yards and 1 TD on 16 carries.
For Tech, Taylor Potts completed 23 of 37 passes for 227 passes and 1 TD before being pulled in the fourth quarter. Steven Sheffield came on to completed 11 of 14 passes for 129 yards and 2 TDs. Detron Lewis caught 8 passes for 111 yards.
Aggie running back Christian Michael suffered a broken leg in the fourth quarter and will be lost for the rest of the season.
Texas A&M (5-3, 2-2 Big 12) now prepares to host Oklahoma next Saturday.