Khris Middleton led A&M with 16 points but was the only Aggie in double figures.
Texas raced to a 20-4 lead in the first seven minutes of play.
Texas A&M pulled back to within five, 24-19, at the 8:31 mark in the first half, but that was as close as the Aggies would come.
The Horns had a 39-27 halftime lead, and extended the lead to as many as 23 points in the second half..
Texas (15-3, 3-0 Big 12) was on fire, shooting 58% from the field and 86% from the free throw line, and outrebounded the Aggies, 31-23..
The Aggies managed just 41% from the field and 58% from the line.
Texas A&M (16-2, 3-1 Big 12) will attempt to bounce back from this tough road loss when they host Kansas State on Saturday afternoon.