Its the Aggies third straight win and earns them a bye in the first round of the Big 12 conference tourney.
The Aggies have now won five of the last eight meetings with Oklahoma, but this was just its second win in fourteen attempts in Norman.
Oklahoma (13-17, 4-12) loses its eighth game in a row, the school's longest losing streak since February 1969.
Oklahoma opened up an early nine-point lead over the Aggies, 23-14, when Tommy Mason-Griffin made a layup with 8:10 to go in the first half. From that point it as all Aggies, as over the final 28 minutes, Big 12 scoring defense leader Texas A&M outscored the Sooners 55-31.
The Sooners were within 38-36 when forward Tiny Gallon, who had averaged 19 points and 12 rebounds in his last two games, rolled his ankle while landing after blocking a Khris Middleton jumper. Gallon had to be helped off the floor with 18:12 remaining and was noticeably limping when he briefly tried to return twice later.
Soon after Gallon was injured, Middleton hit a 3-pointer and B.J. Holmes followed with a three-point play and a 3-pointer as Texas A&M scored nine straight points to take a 50-38 lead.
From there, the Aggies cruised to an easy 69-54 win over the Sooners.
The Aggies held Oklahoma to only 22 points on 24 percent shooting in the second half, the Sooners' lowest second-half scoring total of the season.
Texas A&M was dominant inside, outrebounding the Sooners 33-22, and outscoring the Sooners 38-16 in the paint.
In addition to Middleton's 15 points and Davis' 13 points and 10 rebounds, Donald Sloan scored 10 points and B.J. Holmes 9. Forwards Nathan Walkup and Ray Turner came off the bench to pull down 8 and 5 rebounds, respectively.
Mark Turgeon enjoyed his 100th game as head coach at Texas A&M, improving his A&M career record to 71-29.
"I thought defensively we were as good as we've been," coach Turgeon said after the game. "The reason that we're so successful is that these guys bring an unbelievable amount of toughness to the program. ,A lot of the games that we've won over the last four years with these guys have been because of toughness."
The Aggie win over Oklahoma, coupled with Kansas' win over Missouri, assures Texas A&M of a top 4 finish in the Big 12, earning the Aggies a first round bye in next week's Big 12 conference tourney.
The Sooners will be the 10th seed at the Big 12 tournament next week and face rival Oklahoma State in the opening round on Wednesday while trying to avoid a ninth straight loss for the first time since 1964.