The win gives Kliff Kingsbury his first victory as a head coach.
Texas Tech true freshman quarterback Baker Mayfield finished the game going 43-for-60 for 413 yards and four touchdowns. Also added 16 yards rushing on 12 carries and one touchdown.
Mayfield, a true freshman walk-on quarterback, is the first quarterback with that classification to have ever started a season-opener for a BCS school.
Garrett Gilbert went 41-for-62 for 388 yards no touchdowns.
The Red Raiders have won 11-straight season openers. The last time Tech lost an opener was in 2002 to eventual BCS National Champion Ohio State.