White broke Heisman Trophy winner Josh Heupel's record in the third quarter with his 54th career touchdown pass. Fullback J.D. Runnels caught White's pass in the right flat and took it into the end zone to put Oklahoma ahead 21-6. Travis Wilson caught his second touchdown pass of the game in the fourth quarter to make it 28-6.
White appeared a little late on several passes in the first half when he had only 55 yards passing, but was on the mark when he needed to after halftime. He finished with 151 yards - his fewest of the season - on 15-for-24 passing.
Peterson, making his first start in place of injured Kejuan Jones, scored on a 1-yard touchdown run in the first quarter and exceeded 100 yards rushing for his fourth straight game.
Peterson set up Oklahoma's first score with a 61-yard rush around the right end and down the sideline. Texas Tech's Khalid Naziruddin caught Peterson at an angle and dove to tackle the freshman as he tried to turn toward the goal post. Three plays later, Peterson bounced off a couple tackles and reached the ball across the goal line to make it 7-0.
Peterson had a 57-yard touchdown run in the third quarter negated by a holding call against Jammal Brown. He lay face down on the field briefly after a short run in the fourth quarter, but jogged off after trainers came out to tend to him.
The Sooners kept Texas Tech's prolific offense out of the red zone until the fourth quarter, holding the Red Raiders to Alex Trlica's two field goals until less than 5 minutes were left in the game.
The Red Raiders finally got into the end zone on an 8-yard run by Johnnie Mack to cut it 28-13 with 4:50 to play, but Oklahoma recovered the ensuing onside kick and ran out the clock.
Tech quarterback Sonny Cumbie, who entered the game as the nation's leading passer, looked sharp at times but committed four turnovers - a fumble and three interceptions. He was 36-for-55 for 369 yards, 60 below his average.
While Cumbie had the better passing total, White had perhaps the day's best play. After eluding a Texas Tech blitzer, White stepped up and zipped a 9-yard pass to Wilson, whose defender slipped in the end zone.
Wilson earlier beat Nazirudden in the back, right corner of the end zone, and White tossed the pass to Wilson in stride for a 10-yard score to put Oklahoma ahead 14-3.
White nearly had another touchdown pass on a 34-yard toss in the first quarter, but Mark Clayton couldn't hold the ball after leaping to catch it between two Texas Tech defenders.
Stoops has won all five meetings against the Red Raiders since his former offensive coordinator, Mike Leach, became coach of the Red Raiders in 2000.
Texas Tech Falls At No. 2 Oklahoma
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