"We got some big games out of our posts," said Tech coach Marsha Sharp. "We worked hard the last week trying to involve our post players and be more balanced in our scoring."
The most unexpected performance came from Ayers, who made 7-of-8 shots from the field. Ayers scored 17 of her points in the second half, when Tech stretched a 35-29 halftime lead to double-digits.
The trio of players combined for 61 of Tech's 77 points. The Lady Raiders (13-6, 6-5 Big 12) overcame 20 turnovers and bounced back from a 76-63 loss to ninth-ranked Kansas State on Sunday.
Texas A&M (10-10, 2-6) has lost five straight games, which have all been to Top 25 teams.
"Their inside game really hurt us," said A&M coach Peggie Gillom. "We just gave up Ayers' points. There was nothing special about what she did. We just didn't pressure people."
The Lady Raiders shot 57 percent, while capitalizing on their height advantage in the paint. Tech took just eight shots from outside the arc.
Kim Moore led the Aggies with 17 points, even though she made just 4-of-14 shots.
The Lady Raiders wasted little time responding to an early 12-11 Aggie lead. Tech shot 70 percent through the first 13 minutes to pull out to an 11-point lead.
The Aggies' complete starting lineup was put on the floor following a 12-2 run by the Raiders, and held Tech to 30 percent from the floor in the final six minutes of the half while cutting the lead to 35-29.
LaToya Rose opened up the second half with five points for A&M as part of a 7-1 run that tied the game at 36. Ayers help push the Red Raiders back out to 54-44.