Tech guard Kari Jo Simmons was the last Lady Raider to score, but she raced the length of the court for a lay-up as time expired.
Four players reached double-digits in scoring for Tech, which moved to 17-9 overall and 8-7 in Big 12 action with the win. Nebraska fell to 14-14 overall and 4-11 in conference.
Tech trailed 4-0 early in the contest but quickly regrouped and took its first lead of the game at 5-4 on a 3-pointer by guard Natalie Ritchie with 17:52 left before halftime.
Nebraska forward Katie Robinette made a jump shot shortly thereafter to give the Cornhuskers their last lead of the game at 6-5.
From that point, the Lady Raiders regained the lead and extended it to a 45-24 halftime advantage.
Tech senior guard Candi White finished with 12 points, seven assists and three steals.
White and fellow seniors Tanisha Ellison and Amber Tarr were escorted by their parents and honored during pre-game announcements.
White said she had a good feeling about her last regular season home game.
"It always feels good to play in the United Spirit Arena," White said. "All day I wasn't sure how I was going to be. It was just great running out in the crowd. My Dad got a little emotional so I was like, 'Stop Dad,' because then I would. I just tried to enjoy every moment of it."
Ellison finished with an 11-point, five-rebound performance.
Ellison said during her career at Tech, she's improved on-and-off the court.
"My past four years have been great," Ellison said. "I feel like I have improved a lot on and off the court since my freshman year. I feel like now I am able to do a lot more things that I couldn't do my freshman year."
Tarr missed the game due to back spasms, which stemmed from an incident in practice several days ago.
"I have immaculate timing," said Tarr. "It was pretty disappointing, but I was happy with the performance our team had and the win."
Ritchie filled in for Tarr and tied her career high with 21 points. She buried a career high six 3-pointers.
Lady Raider coach Marsha Sharp said she was pleased with Ritchie's effort.
"I was really proud that she took that challenge," Sharp said. "Obviously we don't want to play many games without Amber right now because she is a big part of us. But Natalie really came onto the floor and took that position over and played really well."
Jia Perkins added 23 points, seven assists and five steals for Tech.